Attenuated Stroke Severity After Prodromal TIA

Attenuated stroke severity after prodromal TIA: a role for ischemic tolerance in the brain?

BACKGROUND AND PURPOSE Ischemic tolerance has been extensively studied in experimental models of heart and brain ischemia. While there is some clinical evidence of ischemic tolerance in the heart, it is not known whether the same is true for the human brain. METHODS We conducted a retrospective case-control study in 148 stroke patients with and without antecedent TIA. RESULTS Despite no sig...

"Attenuated Psychosis Syndrome" or "Subthreshold Prodromal State"?

Psychotic disorders, such as schizophrenia, are the most disabling mental illnesses affecting, usually, young people. Several projects have recently focused on people with pro-dromal symptoms but not frankly psychotic. There is evidence that interventions in early stages of the disease could result in better outcomes. 1 In 1987, the DSM-III-R (American Psychiatric Association) provided a list o...

DWI lesions and TIA etiology improve the prediction of stroke after TIA.

BACKGROUND AND PURPOSE The ABCD(2) score has been shown to predict the early risk of stroke after transient ischemic attack (TIA). The additional predictive value of diffusion-weighted imaging (DWI) and TIA etiology is not well known. METHODS From January 2003 to June 2007, 343 consecutive patients (mean+/-SD age, 62.4+/-15.4 years) with TIA were admitted to our stroke unit. Most (339) patien...

Predicting short-term risk of stroke after TIA.

Evidence Summary Five to 10 percent of patients presenting with TIA will have a stroke within the following week.1-3 Because guidelines do not mandate hospitalization for patients who have had a TIA or suspected TIA,4,5 validated clinical prediction rules may be used to identify patients who should definitely be hospitalized for expedited evaluation and patients for whom outpatient evaluation i...

Dipyridamole + ASA for secondary prevention after a stroke or TIA